Zu "K11420" wurden 78 Artikel gefunden!
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CM-272
Artikelnummer: TGM-T7194-100mg
Description: CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. Target: DNA Methyltransferase, Apoptosis, Histone Methyltransferase. Smiles: COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1. References: San José-Enériz, Edurne, Agirre X , Rabal O , et al. Discovery of first-in-class reversible...
| Anwendung: | EHMT2/EHMT1/DNMT1/DNMT3A/DNMT3B inhibitor |
| CAS | 1846570-31-7 |
| MW: | 478.63 D |
ab 67,00 €
BIX-01294
Artikelnummer: TGM-T7697-100mg
Description: BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 µM). Target: Autophagy, Histone Methyltransferase. Smiles: N(C=1C2=C(N=C(N1)N3CCN(C)CCC3)C=C(OC)C(OC)=C2)C4CCN(CC5=CC=CC=C5)CC4. References: Cui J , Sun W , Hao X , et al. EHMT2 inhibitor BIX-01294 induces apoptosis through...
| Anwendung: | HMTase inhibitor |
| CAS | 935693-62-2 |
| MW: | 490.64 D |
ab 34,00 €
BRD9539
Artikelnummer: TGM-T7378-100mg
Description: BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 µM. Target: Histone Methyltransferase. Smiles: OC(=O)c1ccc2n(CCCc3ccccc3)c(NC(=O)c3ccccc3)nc2c1. References: Yuan Y , Wang Q , Paulk J , et al. A Small-Molecule Probe of the Histone...
| Anwendung: | G9a / PRC2 inhibitor |
| CAS | 1374601-41-8 |
| MW: | 399.44 D |
ab 31,00 €
UNC0321 TFA
Artikelnummer: TGM-T84496-10mg
Target: Others. Smiles: C(C(O)=O)(F)(F)F.N(C=1C2=C(N=C(N1)N3CCN(C)CCC3)C=C(OCCOCCN(C)C)C(OC)=C2)C4CCN(C)CC4
| Anwendung: | G9a HMTase inhibitor |
| CAS | 1934302-25-6 |
| MW: | 857.76 D |
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UNC0646
Artikelnummer: TGM-TQ0232-100mg
Description: UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells) and exhibits low cellular toxicity (EC50: 4.7 µM in MCF7...
| Schlagworte: | UNC 0646 |
| Anwendung: | Potent, selective EHMT1 / EHMT2 inhibitor |
| CAS | 1320288-17-2 |
| MW: | 621.9 D |
ab 58,00 €
BRD4770
Artikelnummer: TGM-T1923-100mg
Description: BRD4770, a histone methyltransferase G9a inhibitor, induces cell senescence. Target: Histone Methyltransferase. Smiles: COC(=O)c1ccc2n(CCCc3ccccc3)c(NC(=O)c3ccccc3)nc2c1. References: Yuan Y, et al. ACS Chem Biol. 2012, 7(7), 1152-1157.
| Anwendung: | EHMT2 inhibitor |
| CAS | 1374601-40-7 |
| MW: | 413.47 D |
ab 31,00 €
UNC0321
Artikelnummer: Cay41100-10
UNC0321 is an inhibitor of the histone methyltransferases G9a and G9a-like protein (GLP, IC50s = 9 and 15 nM, respectively). It is selective for G9a and GLP over SET domain-containing protein 7 (SET7), SET8, protein arginine methyltransferase 3 (PRMT3), and jumonji domain-containing 2E (JMJD2E, IC50s = >10,000 nM...
| Schlagworte: | 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-q... |
| Anwendung: | G9a (EHMT1) / GLP (EHMT2) inhibitor |
| CAS | 1238673-32-9 |
| MW: | 515.7 D |
ab 136,00 €
UNC0224
Artikelnummer: TGM-T17203-100mg
Description: UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM. Target: Histone Methyltransferase. Smiles: COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCCN(C)C)N1CCCN(C)CC1. References: Liu F, et al. Protein lysine...
| Anwendung: | G9a HMTase inhibitor |
| CAS | 1197196-48-7 |
| MW: | 485.67 D |
ab 46,00 €
UNC0321
Artikelnummer: TGM-T17204-100mg
Description: UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays. Target: Histone Methyltransferase. Smiles:...
| Anwendung: | G9a (EHMT1) / GLP (EHMT2) inhibitor |
| CAS | 1238673-32-9 |
| MW: | 515.69 D |
ab 40,00 €
UNC0638
Artikelnummer: TGM-T3257-100mg
Description: UNC0638 is an inhibitor of beta-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. Target: Influenza Virus, Histone Methyltransferase, Autophagy. Smiles:...
| Anwendung: | G9a HMTase inhibitor |
| CAS | 1255580-76-7 |
| MW: | 509.73 D |
ab 55,00 €
A-366
Artikelnummer: TGM-T3624-100mg
Description: A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an...
| Schlagworte: | A366, A 366 |
| Anwendung: | EHMT2 inhibitor |
| CAS | 1527503-11-2 |
| MW: | 329.44 D |
ab 31,00 €
BIX01294 (hydrochloride hydrate)
Artikelnummer: TGM-T35567-10mg
Description: The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte...
| Anwendung: | G9a HMTase inhibitor |
| CAS | 1808255-64-2 |
| MW: | 618.04 D |
ab 75,00 €