BRD7389

Description: BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 µM, 2.4 µM, and 1.2 µM for RSK1, RSK2, and RSK3, respectively. Target: FLT, DAPK, SGK, CDK, Pim, S6 Kinase. Smiles: O=C1c2ccccc2-c2c(NCCc3ccccc3)c(=O)[nH]c3cccc1c23. References: Park YS, et al. EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012 Nov,370(1-2):191-8.