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Zu "K04373" wurden 180 Artikel gefunden!
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Artikelnummer: ELK-ELK7155.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RPS6Ka1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RPS6Ka1....
Schlagworte: | RSK-1, p90S6K, RPS6KA1, p90RSK1, p90-RSK 1, MAPKAPK1A, MAPKAPK-1a, S6K-alpha-1, EC=2.7.11.1, MAPKAP kinase 1a, Ribosomal... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
365,00 €
ab 328,50 €
Artikelnummer: Cay15264-1
The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively). At 100...
Schlagworte: | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridinone |
Anwendung: | RSK1/2/3/4 inhibitor |
CAS | 501437-28-1 |
MW: | 391.4 D |
ab 76,00 €
Artikelnummer: Cay11704-1
The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 µM) without interfering with upstream...
Schlagworte: | 3-[(3,4-di-O-acetyl-6-deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
Anwendung: | RSK2 inhibitor |
CAS | 77307-50-7 |
MW: | 516.5 D |
ab 77,00 €
Artikelnummer: Cay19913-10
LJH685 is an inhibitor of p90 ribosomal S6 kinases (RSKs, also known as MAP kinase-activated protein kinases, or MAPKAPKs) that inhibits RSK1, 2, and 3 in vitro with IC50 values of 6, 5, and 4 nM, respectively. It is selective for RSKs over a panel of 96 other kinases. LJH685 blocks RSK activity in cells, preventing...
Schlagworte: | 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-phenol |
Anwendung: | RSK inhibitor |
CAS | 1627710-50-2 |
MW: | 381.4 D |
ab 43,00 €
Artikelnummer: Cay19183-1
The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. Phosphorylation of the sodium-hydrogen exchanger (NHE) in cardiac tissue by RSK has been shown to activate NHE during cellular stresses, such as myocardial...
Schlagworte: | (5R)-N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole... |
Anwendung: | RSK2 inhibitor |
CAS | 1311367-27-7 |
MW: | 458.6 D |
ab 48,00 €
Artikelnummer: Cay19924-1
LJI308 is a selective and potent inhibitor of the p90 ribosomal S6 kinase (RSK) family with IC50 values ranging from 4 to 13 nM for RSK isoforms 1-3. In a panel of 442 kinases, LJI308 is selective for RSK1, RSK3, and RSK4. It also inhibits S6K1, MEK4, and HIP in the low micromolar range but had no effect on other...
Schlagworte: | 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-phenol |
Anwendung: | RSK inhibitor |
CAS | 1627709-94-7 |
MW: | 368.4 D |
ab 60,00 €
Artikelnummer: Cay20214-5
BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs, IC50s = 1.5, 2.4, and 1.2 µM for RSK1, RSK2, and RSK3, respectively). Through this action, BRD7389 causes mouse alphaTC1 pancreatic alpha cells to adopt several morphological and gene expression features of beta cells, including increased insulin expression....
Schlagworte: | 1-[(2-phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
Anwendung: | RSK1 / RSK2 / RSK3 inhibitor |
CAS | 376382-11-5 |
MW: | 366.4 D |
ab 44,00 €
Artikelnummer: Cay9000887-5
FMK is an inhibitor of p90 ribosomal S6 kinase 3alpha (RSK2, IC50 = 15 nM). It inhibits the C-terminal domain (CTD) kinase activity of RSK2 and inhibits EGF-induced phosphorylation of RSK2 Ser386 in serum-starved COS-7 cells (EC50 = ~200 nM). FMK (6 µM) reduces invasion, but not proliferation, of M4e, 212LN, and 37B...
Schlagworte: | Fluoromethyl Ketone, Fluoromethyl Ketone-MEA, FMK-MEA,... |
Anwendung: | RSK2 inhibitor |
CAS | 821794-92-7 |
MW: | 342.4 D |
ab 60,00 €
Artikelnummer: ARG51607.100
Protein function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular...
Schlagworte: | Anti-phospho-RSK-1, Anti-phospho-p90S6K, Anti-phospho-RPS6KA1, Anti-phospho-p90RSK1, Anti-phospho-p90-RSK 1,... |
Anwendung: | ICC, IF, IHC (paraffin), WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 436,00 €
Artikelnummer: ARG51615.100
Protein function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular...
Schlagworte: | Anti-phospho-RSK-1, Anti-phospho-p90S6K, Anti-phospho-RPS6KA1, Anti-phospho-p90RSK1, Anti-phospho-p90-RSK 1,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 436,00 €
Artikelnummer: ARG55903.100
Protein function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular...
Schlagworte: | Anti-RSK-1, Anti-p90S6K, Anti-p90RSK1, Anti-RPS6KA1, Anti-MAPKAPK1A, Anti-p90-RSK 1, Anti-MAPKAPK-1a, EC=2.7.11.1,... |
Anwendung: | WB, IP |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse, monkey |
624,00 €
Artikelnummer: A302-458A
Protein function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular...
Schlagworte: | Anti-RSK-1, Anti-p90S6K, Anti-RPS6KA1, Anti-p90RSK1, Anti-MAPKAPK1A, Anti-p90-RSK 1, Anti-MAPKAPK-1a, Anti-S6K-alpha-1,... |
Anwendung: | WB, IP, IHC-IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €