BRD6929

BRD6929 is a histone deacetylase 1 (HDAC1) and HDAC2 inhibitor (IC50s = 0.04 and 0.1 µM, respectively, for the recombinant human enzymes). It is selective for HDAC1 and HDAC2 over HDAC3 and HDAC8 (IC50s = >20 µM for both). BRD6929 inhibits proliferation of HCT116 human colon cancer cells but not non-cancerous human mammary epithelial cells (HMECs, IC50s = 4 and >50 µM, respectively).Formal Name: 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-benzamide. CAS Number: 849234-64-6. Synonyms: JQ12. Molecular Formula: C19H17N3O2S. Formula Weight: 351.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 282 nm. SMILES: O=C(C1=CC=C(NC(C)=O)C=C1)NC2=C(N)C=CC(C3=CC=CS3)=C2. InChi Code: InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24). InChi Key: ABZSPJVXTTUFAA-UHFFFAOYSA-N.