BPKDi

BPKDi is an inhibitor of protein kinase D (PKD, IC50s = 1, 9, and 1 nM for PKD1, PKD2, and PKD3, respectively). It is selective for PKD over PKCdelta and PKCepsilon, as well as over a panel of additional calcium/calmodulin-dependent protein kinase (CaMK) superfamily members, at 1 µM. It inhibits phenylephrine-induced phosphorylation and nuclear export of histone deacetylase 4 (HDAC4) and HDAC5 in, as well reduces phenylephrine-induced hypertrophy of, isolated neonatal rat ventricular myocytes when used at a concentration of 1 µM.Formal Name: 2'-(cyclohexylamino)-6-(1-piperazinyl)-[2,4'-bipyridine]-4-carboxamide. CAS Number: 1201673-28-0. Molecular Formula: C21H28N6O. Formula Weight: 380.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C1=CC(N2CCNCC2)=NC(C3=CC=NC(NC4CCCCC4)=C3)=C1)N. InChi Code: InChI=1S/C21H28N6O/c22-21(28)16-12-18(26-20(14-16)27-10-8-23-9-11-27)15-6-7-24-19(13-15)25-17-4-2-1-3-5-17/h6-7,12-14,17,23H,1-5,8-11H2,(H2,22,28)(H,24,25). InChi Key: XNWDRALEEPGBHB-UHFFFAOYSA-N.