BMS 753

BMS 753 is a synthetic retinoid and retinoic acid receptor alpha (RARalpha) agonist (Ki = 2 nM). It is selective for RARalpha over RARgamma at 1 µM. BMS 753 (10 and 100 nM) induces morphological differentiation of P19 embryonal carcinoma cells, as well as F9 embryonal carcinoma cells when used at a concentration of at 100 nM in combination with the pan-retinoid X receptor (RXR) agonist BMS649.Formal Name: 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid. CAS Number: 215307-86-1. Molecular Formula: C21H21NO4. Formula Weight: 351.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 289 nm. SMILES: OC(C1=CC=C(NC(C2=CC(C(C)(C)C(C3(C)C)=O)=C3C=C2)=O)C=C1)=O. InChi Code: InChI=1S/C21H21NO4/c1-20(2)15-10-7-13(11-16(15)21(3,4)19(20)26)17(23)22-14-8-5-12(6-9-14)18(24)25/h5-11H,1-4H3,(H,22,23)(H,24,25). InChi Key: KFBPBWUZXBYJDG-UHFFFAOYSA-N.