BML-260

BML-260 is an inhibitor of dual-specificity phosphatase 22 (DUSP22). In vivo, BML-260 (1 mg/kg) increases expression of Ucp1, the gene encoding the thermogenic protein uncoupling protein 1 (Ucp1), in white adipocytes and induces thermogenesis in mice. Xenotransplantation of BML-260-expanded hematopoietic stem cells (HSCs) increases immune cell content in immunocompromised mice.. Solulibility: DMSO: Soluble: =10 mg/ml: .