BIMU 8

BIMU 8 is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69 nM). It also binds 5-HT3 receptors (Ki = 0.36 nM). It stimulates cAMP formation in primary mouse embryonic colliculi neurons with an EC50 value of 72 nM. BIMU 8 (30, 40, and 60 nmol/animal, i.c.v.) induces acetylcholine release in the rat frontal cortex. It increases postprandial antral and colonic motility in conscious dogs when administered at doses of 0.1, 0.3, and 1 mg/kg. BIMU 8 (20 mg/kg, i.p.) also increases the latency to withdraw in the paw pressure test in rats.Formal Name: 2,3-dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide, monohydrochloride. CAS Number: 134296-40-5. Molecular Formula: C19H26N4O2 . HCl. Formula Weight: 378.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 75 mM. SMILES: O=C(N1C(N(C(C)C)C2=C1C=CC=C2)=O)N[C@@H]3C[C@@H]4CC[C@@H](N4C)C3.Cl. InChi Code: InChI=1S/C19H26N4O2.ClH/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3,/h4-7,12-15H,8-11H2,1-3H3,(H,20,24),1H/t13-,14+,15-,. InChi Key: NQYXXIUVFVOJCX-NFWSUKNGSA-N.