Zu "K04160" wurden 56 Artikel gefunden!
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CJ-033466
Artikelnummer: Cay42394-1
CJ-033466 is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4. It induces cAMP accumulation in HEK293 cells expressing human 5-HT4D receptors and relaxation of rat tunica muscularis mucosae strips (EC50s = 0. and 1. nM, respectively). CJ-033466 selectively binds to 5-HT4D over 5-HT1A, 5-HT1B, 5-HT1D,...
| Schlagworte: | 5-amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)-4-piperidinyl]methyl]-imidazo[1,2-a]pyridine-8-carboxamide |
| Anwendung: | 5-HT4 receptor partial agonist |
| CAS | 519148-48-2 |
| MW: | 377.91 D |
ab 42,00 €
Mosapride (citrate)
Artikelnummer: Cay30048-10
Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and alpha1- and alpha2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic...
| Schlagworte: | AS-4370, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide,... |
| Anwendung: | Serotonin receptor subtype 5-HT4 agonist |
| CAS | 112885-42-4 |
| MW: | 614 D |
ab 85,00 €
Cisapride
Artikelnummer: Cay21657-5
Cisapride is an agonist of serotonin (5-HT) receptor subtype 5-HT4 (IC50 = 0.483 µM in COS-7 cells expressing the human receptor). It induces relaxation of precontracted isolated rat esophageal thoracic muscularis mucosae preparations (EC50 = 102.33 nM). Cisapride (0.5 mg/kg) increases the rate of gastric emptying...
| Schlagworte: | rel-4-amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-benzamide |
| Anwendung: | 5-HT4 agonist |
| CAS | 81098-60-4 |
| MW: | 466 D |
ab 67,00 €
Tegaserod (maleate)
Artikelnummer: Cay14692-5
Tegaserod (maleate) is a potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM). As 5-HT4 receptors are associated with cholinergic nerves lining the colon, tegaserod (maleate) stimulates colonic motility and transit in vivo, in both healthy and diseased gastrointestinal tracts. However, it lacks...
| Schlagworte: | SDZ-HTF 919, Zelnorm, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide, 2Z-butenedioate |
| Anwendung: | HTR4 agonist |
| CAS | 189188-57-6 |
| MW: | 417.5 D |
ab 110,00 €
Prucalopride
Artikelnummer: Cay24192-10
Prucalopride is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Kis = 2.5 and 8 nM for human 5-HT4A and 5-HT4B, respectively). Prucalopride is greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human dopamine...
| Schlagworte: | 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide |
| Anwendung: | Serotonin receptor 5-HT4 agonist |
| CAS | 179474-81-8 |
| MW: | 367.9 D |
ab 85,00 €
SB-207266
Artikelnummer: Cay18778-1
The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1.{34073, 34070} In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production. In several animal models, low...
| Schlagworte: | Piboserod, N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide |
| Anwendung: | 5-HT(4) receptor antagonist |
| CAS | 152811-62-6 |
| MW: | 369.5 D |
ab 49,00 €
GR113808
Artikelnummer: Cay28733-10
GR113808 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT4. It binds to 5-HT4 receptors with an IC50 value of 0.4 nM in COS-7 cells expressing the human recombinant receptor and in guinea pig striatal membranes (IC50 = 0.5 nM). GR113808 is selective for 5-HT4 receptors over 5-HT1 receptors (Kis = >10...
| Schlagworte: | 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester |
| Anwendung: | Serotonin (5-HT) receptor subtype 5-HT4 antagonist |
| CAS | 144625-51-4 |
| MW: | 393.5 D |
ab 139,00 €
PF-04995274
Artikelnummer: Cay28776-1
PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36,...
| Schlagworte: | tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-2H-pyran-4-ol |
| Anwendung: | 5-HT4A / 5-HT4B / 5-HT4D / 5-HT4E partial agonist |
| CAS | 1331782-27-4 |
| MW: | 432.5 D |
ab 52,00 €
Cisapride-d6
Artikelnummer: Cay28701-1
Cisapride-d6 is intended for use as an internal standard for the quantification of cisapride (Cay-21657) by GC- or LC-MS. Cisapride is an agonist of serotonin (5-HT) receptor subtype 5-HT4 (IC50 = 0.483 µM in COS-7 cells expressing the human receptor). It induces relaxation of precontracted isolated rat esophageal...
| Schlagworte: | rel-4-amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl-d6]-3-methoxy-4-piperidinyl]-2-methoxy-benzamide |
| Anwendung: | GC-MS, LC-MS, internal standard, 5-HT4 agonist |
| MW: | 472 D |
ab 325,00 €
BIMU 8
Artikelnummer: Cay30964-1
BIMU 8 is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69 nM). It also binds 5-HT3 receptors (Ki = 0.36 nM). It stimulates cAMP formation in primary mouse embryonic colliculi neurons with an EC50 value of 72 nM. BIMU 8 (30, 40, and 60 nmol/animal, i.c.v.) induces acetylcholine release in the rat...
| Schlagworte: | 2,3-dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide,... |
| Anwendung: | 5-HT4 receptor agonist |
| CAS | 134296-40-5 |
| MW: | 378.9 D |
ab 60,00 €
Anti-HTR4
Artikelnummer: ATA-HPA040591.100
Protein function: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. [The UniProt Consortium] Buffer: 40%...
| Schlagworte: | Anti-HTR4, Anti-5-HT4, Anti-5-HT-4, Anti-Serotonin receptor 4, Anti-5-hydroxytryptamine receptor 4 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Des-4-fluorobenzyl Mosapride
Artikelnummer: Cay22157-2.5
Des-4-fluorobenzyl Mosapride is the primary metabolite of mosapride. Mosapride is a gastroprokinetic agent that enhances upper GI motility by activating serotonin receptor 4 (5-HT4, EC50 = 74.2 nM, in guinea pig ileal longitudinal muscle myenteric plexus). Mosapride increases canine, equine, and guinea pig colonic...
| Schlagworte: | Des-p-fluorobenzyl Mosapride, 4-amino-5-chloro-2-ethoxy-N-(2-morpholinylmethyl)-benzamide |
| Anwendung: | Mosapride metabolite |
| CAS | 152013-26-8 |
| MW: | 313.8 D |
378,00 €