Bifemelane (hydrochloride)

Bifemelane is an inhibitor of monoamine oxidase A (MAO-A, Ki = 4.2 µM). It is selective for MAO-A over MAO-B (Ki = 46 µM). Bifemelane (15 mg/kg, p.o.) protects against ischemia-induced decreases in frontal cortex, hippocampus, and striatum levels of muscarinic acetylcholine receptors (mAChRs) in a rat model of chronic cerebral hypoperfusion induced by permanent bilateral carotid artery occlusion. It also increases survival and brain norepinephrine, dopamine, and serotonin (5-HT) levels in a gerbil model of cerebral ischemia induced by bilateral carotid artery ligation when administered at a dose of 25 mg/kg. Bifemelane (30 mg/kg, i.p.) prevents memory deficits induced by scopolamine (Item No. 40307) in the passive avoidance test in rats. It decreases immobility time in the forced swim test in rats. Formulations containing bifemelane have been used in the treatment of depression in patients with cerebral infarction or senile dementia. SMILES CNCCCCOC1=C(CC2=CC=CC=C2)C=CC=C1.Cl InChi Code InChI=1S/C18H23NO.ClH/c1-19-13-7-8-14-20-18-12-6-5-11-17(18)15-16-9-3-2-4-10-16,/h2-6,9-12,19H,7-8,13-15H2,1H3,1H InChi Key MEAHDXWXNNDSAK-UHFFFAOYSA-N