BIBF 1202

BIBF 1202 is an active metabolite of the VEGFR, FGFR, and PDGFR inhibitor BIBF 1120 (nintedanib, Cay-11022). It is formed from BIBF 1120 by intracellular esterases. BIBF 1202 inhibits VEGFR2 with an IC50 value of 62 nM.Formal Name: (3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid. CAS Number: 894783-71-2. Molecular Formula: C30H31N5O4. Formula Weight: 525.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: CN(C(CN1CCN(C)CC1)=O)C(C=C2)=CC=C2N/C(C3=CC=CC=C3)=C4C(NC5=C\4C=CC(C(O)=O)=C5)=O. InChi Code: InChI=1S/C30H31N5O4/c1-33-14-16-35(17-15-33)19-26(36)34(2)23-11-9-22(10-12-23)31-28(20-6-4-3-5-7-20)27-24-13-8-21(30(38)39)18-25(24)32-29(27)37/h3-13,18,31H,14-17,19H2,1-2H3,(H,32,37)(H,38,39)/b28-27-. InChi Key: KEHNCEDHZGQSNP-DQSJHHFOSA-N.