BI-7273

BI-7273 is a potent BRD9 bromodomain inhibitor (Kd = 15.4 nM, IC50 = 19 nM) that less effectively inhibits the functionally and structurally related BRD7 bromodomain (IC50 = 117 nM). It is without effect against the bromodomains of BRD2 and BRD4, as well as a panel of kinases. BI-7273 inhibits the growth of EOL-1 acute myeloid leukemia cells in vitro (EC50 = 1.4 µM).Formal Name: 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one. CAS Number: 1883429-21-7. Molecular Formula: C20H23N3O3. Formula Weight: 353.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml, Ethanol: 0.2 mg/ml, PBS (pH 7.2): 0.1 mg/ml. lambdamax: 254, 321 nm. SMILES: CN(C)CC1=C(OC)C=C(C(C2=C3C=NC=C2)=CN(C)C3=O)C=C1OC. InChi Code: InChI=1S/C20H23N3O3/c1-22(2)11-17-18(25-4)8-13(9-19(17)26-5)16-12-23(3)20(24)15-10-21-7-6-14(15)16/h6-10,12H,11H2,1-5H3. InChi Key: RBUYFHLQNPJMQM-UHFFFAOYSA-N.