BH400

A PPARalpha agonist and STING inhibitor (IC50 = 8.1 µM), induces transactivation of PPARalpha in a reporter assay using THP-1 cells (EC50 = 1.2 µM), inhibits 4-HNE- or H2O2-induced decreases in viability in 661W cells at 10 µM, prevents LPS-induced increases in phosphorylated TBK1 and IL-6 levels and LPS-induced decreases in PGC-1alpha levels in HMC3 cells at 10 µM. Formulation: A solid. InChI: InChI=1S/C20H16FNO3/c21-16-7-5-15(6-8-16)14-3-1-13(2-4-14)12-22-17-9-10-19(23)18(11-17)20(24)25/h1-11,22-23H,12H2,(H,24,25). InChIKey: PEWZEZWZGJQFKN-UHFFFAOYSA-N. SMILES: FC(C=C1)=CC=C1C(C=C2)=CC=C2CNC3=CC=C(O)C(C(O)=O)=C3