BETd-260

Description: BETd-260, a PROTAC linked by a Cereblon ligand and a BET ligand, has an inhibitory effect on BRD4 protein in leukemic cell lines. Target: PROTACs, Epigenetic Reader Domain. Smiles: N(C1=C2C=3C(NC2=NC(C(NCCCCCC4=C5C(C(=O)N(C5)C6C(=O)NC(=O)CC6)=CC=C4)=O)=N1)=CC(=C(OC)C3)C=7C(C)=NOC7C)C=8N(CC)N=C(C8)C9CC9. References: Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25,61(2):462-481.