BE-24566B

BE-24566B is a polyketide fungal metabolite originally isolated from S. violaceusniger. It is active against B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus (MICs = 1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 µg/ml, respectively). BE-24566B is an endothelin (ET) receptor antagonist (IC50s = 11 and 3.9 µM for ETA and ETB receptors, respectively).Formal Name: (6S,16S)-6,7,9,16-tetrahydro-3,11,13,15-tetrahydroxy-1,6,9,9-tetramethyl-6,16-epoxy-14H-anthra[2,3-d][1]benzoxocin-14-one. CAS Number: 149466-04-6. Synonyms: L-755,805. Molecular Formula: C27H24O7. Formula Weight: 460.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(C(C(O)=CC(O)=C1)=C1C2(C)C)C(C2=C3)=C(O)C4=C3C[C@]5(C)OC6=CC(O)=CC(C)=C6[C@H]4O5. InChi Code: InChI=1S/C27H24O7/c1-11-5-13(28)9-18-19(11)25-20-12(10-27(4,33-18)34-25)6-15-22(23(20)31)24(32)21-16(26(15,2)3)7-14(29)8-17(21)30/h5-9,25,28-31H,10H2,1-4H3/t25-,27-/m1/s1. InChi Key: MDUGEFRGUDVHQH-XNMGPUDCSA-N. Origin: Bacterium/Streptomyces sp..