BCTC

The vanilloid receptor 1 (TRPV1) is a ligand-gated ion channel highly expressed on primary nociceptive neurons that respond to a variety of noxious stimuli, including heat, acid, and other chemical irritants. Because disruptions in TRPV1 activity cause reduced thermal nociception and hyperalgesia, this receptor is considered to be a useful target for the discovery of novel analgesics. BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.Formal Name: 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide. CAS Number: 393514-24-4. Molecular Formula: C20H25ClN4O. Formula Weight: 372.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 12.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 247 nm. SMILES: ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2. InChi Code: InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26). InChi Key: ROGUAPYLUCHQGK-UHFFFAOYSA-N.