BAY-293

BAY-293 is an inhibitor of the protein-protein interaction between K-Ras and the guanine nucleotide exchange factor son of sevenless homolog 1 (SOS1, IC50 = 0.021 µM). It inhibits proliferation of K562 and MOLM-13 cells expressing wild-type K-Ras, as well as NCI H358 and Calu-1 cells expressing mutant K-RasG12C with IC50 values of 1.09, 0.995, 3.48, and 3.19 µM, respectively.Formal Name: 6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-4-quinazolinamine. CAS Number: 2244904-70-7. Molecular Formula: C25H28N4O2S. Formula Weight: 448.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 216, 250, 328, 342 nm. SMILES: C[C@H](C1=CC(C2=C(CNC)C=CC=C2)=CS1)NC3=NC(C)=NC4=C3C=C(OC)C(OC)=C4. InChi Code: InChI=1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11-22(30-4)23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29)/t15-/m1/s1. InChi Key: WEGLOYDTDILXDA-OAHLLOKOSA-N.