Zu "K03099" wurden 47 Artikel gefunden!
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BAY-293
Artikelnummer: TGM-T5418-100mg
Description: BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM). Target: Raf, Ras. Smiles: CNCc1ccccc1-c1csc(c1)[C@@H](C)Nc1nc(C)nc2cc(OC)c(OC)cc12. References: Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the...
| Anwendung: | The K-Ras-SOS1 protein-protein interaction inhibitor |
| CAS | 2244904-70-7 |
| MW: | 448.58 D |
ab 48,00 €
MRTX0902
Artikelnummer: TGM-T9755-100mg
Description: MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM. Target: Raf. Smiles: C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(C#N)c1C. References: Ketcham JM, et al. Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable...
| Schlagworte: | UNII-CRG69FR93G |
| Anwendung: | SOS1-K-Ras(G12C) protein-protein interaction inhibitor |
| CAS | 2654743-22-1 |
| MW: | 388.47 D |
ab 86,00 €
Ras Inhibitory Peptide
Artikelnummer: TGM-T37422-10mg
Description: Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains...
| Anwendung: | Ras inhibitor |
| CAS | 159088-48-9 |
| MW: | 1170.433 D |
ab 170,00 €
Anti-SOS1
Artikelnummer: A301-890A
Protein function: Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by...
| Schlagworte: | Anti-SOS1, Anti-SOS-1, Anti-Son of sevenless homolog 1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-SOS2
Artikelnummer: CSB-PA113430.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-SOS2, Anti-SOS-2, Anti-Son of sevenless homolog 2, FLJ25596 antibody, Guanine nucleotide exchange factor antibody,... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €
Anti-SOS2
Artikelnummer: CSB-PA22327A0Rb.100
Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen Affinity Purified. Target Name: SOS2. Antigen Species: Human
| Schlagworte: | Anti-SOS2, Anti-SOS-2, Anti-Son of sevenless homolog 2, FLJ25596 antibody, Guanine nucleotide exchange factor antibody,... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Ras Inhibitory Peptide
Artikelnummer: Cay17474-1
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence...
| Schlagworte: | Sos SH3 Domain Inhibitor |
| Anwendung: | SOS1-Grb3 interaction inhibitor |
| CAS | 159088-48-9 |
| MW: | 1170.4 D |
ab 94,00 €
Anti-SOS1
Artikelnummer: A301-889A
Protein function: Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by...
| Schlagworte: | Anti-SOS1, Anti-SOS-1, Anti-Son of sevenless homolog 1 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
Anti-SOS2
Artikelnummer: A301-893A
Protein function: Promotes the exchange of Ras-bound GDP by GTP. [The UniProt Consortium]
| Schlagworte: | Anti-SOS2, Anti-SOS-2, Anti-Son of sevenless homolog 2 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 178,00 €
SOS1, FLAG-Tag Recombinant
Artikelnummer: BPS-101573
Recombinant human SOS1 (son of sevenless homolog 1), encompassing amino acids 564-1049. This construct contains a C-terminus Flag-tag. This recombinant protein was affinity purified.
| Schlagworte: | SOS1, SOS-1, Son of sevenless homolog 1, SOS1 (564-1049-FLAG) |
| Anwendung: | Ras signaling studies |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 58 kD |
506,00 €
MRTX-0902
Artikelnummer: Cay38578-1
MRTX-0902 is an inhibitor of the protein-protein interaction between son of sevenless homolog 1 (SOS1) and K-Ras containing a glycine-to-cysteine mutation at position 12 (K-RasG12C, Ki = 1.9 nM). It is selective for the SOS1-K-RasG12C protein-protein interaction over the SOS1 and wild-type K-Ras protein-protein...
| Schlagworte: | 2-methyl-3-[(1R)-1-[[4-methyl-7-(4-morpholinyl)pyrido[3,4-d]pyridazin-1-yl]amino]ethyl]-benzonitrile |
| Anwendung: | SOS1-K-Ras(G12C) protein-protein interaction inhibitor |
| CAS | 2654743-22-1 |
| MW: | 388.5 D |
ab 103,00 €
Anti-Sos, clone SOS-01
Artikelnummer: ARG63100.100
Protein function: Promotes the exchange of Ras-bound GDP by GTP. [The UniProt Consortium]
| Schlagworte: | Anti-SOS2, Anti-SOS-2, Anti-Son of sevenless homolog 2 |
| Anwendung: | ICC, IF, WB |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse |
658,00 €