BAY 11-7085

In the classical pathway of NF-kappaB activation, phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) releases the inhibitor from NF-kappaB, allowing IkappaBalpha degradation and NF-kappaB activation and nuclear import. BAY 11-7085 is an irreversible inhibitor of IkappaBalpha phosphorylation, preventing activation of NF-kappaB by cytokines and lipopolysaccharide (IC50 = 10 µM). It blocks gene expression that is regulated through the classical pathway of NF-kappaB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY 11-7085 is also used to study IkappaBalpha actions that are independent of NF-kappaB signaling.Formal Name: 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile. CAS Number: 196309-76-9. Molecular Formula: C13H15NO2S. Formula Weight: 249.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): Insolulble. lambdamax: 205, 252 nm. SMILES: CC(C)(C)C1=CC=C(S(/C=C/C#N)(=O)=O)C=C1. InChi Code: InChI=1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+. InChi Key: VHKZGNPOHPFPER-ONNFQVAWSA-N.