BAY 11-7082

The transcription factor NF-kappaB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. In the cytoplasm, inactive NF-kappaB complexes are bound to an inhibitor IkappaB. However in response to certain stimuli, IkappaB is phosphorylated, ubiquitinated, and degraded, enabling the translocation of NF-kappaB to the nucleus. BAY 11-7082 selectively and irreversibly inhibits NF-kappaB activation by blocking TNF-alpha-induced phosphorylation of IkappaB-alpha without affecting constitutive IkappaB-alpha phosphorylation. This compound inhibits the TNF-alpha-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM.Formal Name: 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile. CAS Number: 19542-67-7. Molecular Formula: C10H9NO2S. Formula Weight: 207.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.20 mg/ml. lambdamax: 251 nm. SMILES: N#C/C=C/S(=O)(=O)c1ccc(C)cc1. InChi Code: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+. InChi Key: DOEWDSDBFRHVAP-KRXBUXKQSA-N. Origin: Synthetic.