Bavachinin

Bavachinin is a natural flavanone first isolated from seeds of P. corylifolia. It is a pan-PPAR agonist (EC50s = 4.0, 8.1, and 0.74 µM for PPARalpha, beta/delta, and gamma, respectively). Bavachinin has synergistic effects when combined with thiazolidinediones or fibrates. It lowers glucose and triacylglycerol levels in db/db mice without inducing weight gain or hepatotoxicity. Bavachinin also has actions that block allergic inflammation, angiogenesis, and Abeta42 aggregation in vitro.Formal Name: (2S)-2,3-dihydro-2-(4-hydroxyphenyl)-7-methoxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one. CAS Number: 19879-30-2. Synonyms: 7-O-Methylbavachin. Molecular Formula: C21H22O4. Formula Weight: 338.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/mL, DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL, DMSO: 30 mg/mL, Ethanol: 20 mg/mL. lambdamax: 219, 233, 273, 320 nm. SMILES: O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C1C=C(C/C=C(C)/C)C(OC)=C3. InChi Code: InChI=1S/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3/t20-/m0/s1. InChi Key: VOCGSQHKPZSIKB-FQEVSTJZSA-N.