Balsalazide-d4

Balsalazide-d4 is intended for use as an internal standard for the quantification of balsalazide (Cay-18680) by GC- or LC-MS. Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA, Cay-70265). It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB). Formulations containing balsalazide have been used in the treatment of ulcerative colitis.Formal Name: (E)-5-((4-((2-carboxyethyl)carbamoyl)phenyl-2,3,5,6-d4)diazenyl)-2-hydroxybenzoic acid. Molecular Formula: C17H11D4N3O6. Formula Weight: 361.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: OC1=CC=C(/N=N/C2=C([2H])C([2H])=C(C(NCCC(O)=O)=O)C([2H])=C2[2H])C=C1C(O)=O. InChi Code: InChI=1S/C17H15N3O6/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26)/b20-19+/i1D,2D,3D,4D. InChi Key: IPOKCKJONYRRHP-AAMHWJAJSA-N.