AZD3458

Description: AZD3458 is a potent and highly selective inhibitor of PI3Kgamma (PI3Kgamma, PI3Kalpha, PI3Kbeta, and PI3Kdelta with pIC50s of 9.1, 5.1, <4.5, and 6.5, respectively). Target: PI3K. Smiles: C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(NC(C)=O)nc1C. References: Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-gamma Inhibitors. J Med Chem. 2018 Jun 28,61(12):5435-5441.