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AZD3458
Artikelnummer: TGM-T12466-100mg
Description: AZD3458 is a potent and highly selective inhibitor of PI3Kgamma (PI3Kgamma, PI3Kalpha, PI3Kbeta, and PI3Kdelta with pIC50s of 9.1, 5.1, <4.5, and 6.5, respectively). Target: PI3K. Smiles: C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(NC(C)=O)nc1C. References: Pemberton N, et al. Discovery of Highly...
| CAS | 2132961-46-5 |
| MW: | 433.54 D |
ab 918,00 €
AZD 3458
Artikelnummer: Cay42104-1
A PI3Kgamma inhibitor (IC50 = 0.79 nM), selective for PI3Kgamma over PI3Kalpha, PI3Kbeta, and PI3Kdelta (IC50s = 7.94, >31.62, and 0.316 µM, respectively), PI3KC2alpha, PI3KC2gamma, and PI3KC3 (IC50s = >10, 3.16, and 7.94 µM, respectively), and a panel of 395 kinases at 1 µM but does inhibit PI3KC2beta (IC50 = 31.62...
| Schlagworte: | N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-(methylsulfonyl)-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]-acetamide |
| Anwendung: | PI3Kgamma inhibitor |
| CAS | 2132961-46-5 |
| MW: | 433.55 D |
ab 116,00 €
