AZD 9750

AZD 9750 is a proteolysis-targeting chimera (PROTAC) composed of an androgen receptor ligand and a lenalidomide derivative. It induces the degradation of wild-type androgen receptor (AR) and drug-resistant mutant AR containing a leucine-to-histidine substitution at position 702 (ARL702H) with half-maximal degradation concentration (DC50) values of 10 and 12 nM, respectively. AZD 9750 (30 mg/kg) decreases tumor volume in a wild-type AR-expressing patient-derived xenograft (PDX) mouse model of prostate cancer.. SMILES: CN1C(C(CC2)CCN2CC(CC3)CCN3C(C=C4)=CC=C4[C@@H]5CCCN(C6=C7NN=C(C#N)C7=C(C=C6)Cl)C5)=CC8=CC=C(N9C(NC(CC9)=O)=O)C=C18. InChi Code: InChI=1S/C43H48ClN9O2/c1-49-38(23-31-6-9-34(24-39(31)49)53-22-16-40(54)46-43(53)55)30-14-18-50(19-15-30)26-28-12-20-51(21-13-28)33-7-4-29(5-8-33)32-3-2-17-52(27-32)37-11-10-35(44)41-36(25-45)47-48-42(37)41/h4-11,23-24,28,30,32H,2-3,12-22,26-27H2,1H3,(H,47,48)(H,46,54,55)/t32-/m1/s1. InChi Key: GOWJHJUMPVCHAN-JGCGQSQUSA-N