AZD 8835

AZD 8835 is an inhibitor of PI3Kalpha and PI3Kdelta (IC50s = 6.2 and 5.7 nM, respectively). It is selective for PI3Kalpha and PI3Kdelta over PI3Kbeta and PI3Kgamma (IC50s = 431 and 90 nM, respectively). AZD 8835 inhibits Akt phosphorylation in PIK3CA constitutively active mutant BT474 cells and Jeko-1 B cells that express endogenous PI3Kdelta (IC50s = 57 and 49 nM, respectively). In vivo, AZD 8835 (25 mg/kg) reduces tumor growth and Akt phosphorylation in a SKOV3 mouse xenograft model. It also increases the activity of CD8+ effector T cells and reduces tumor growth in a C26 mouse syngeneic tumor model.Formal Name: 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-1-propanone. CAS Number: 1620576-64-8. Molecular Formula: C22H31N9O3. Formula Weight: 469.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 16 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 235, 289, 378 nm. SMILES: O=C(CCO)N1CCC(C2=NN(CC)C(C3=CN=C(N)C(C4=NN=C(C(C)(C)C)O4)=N3)=N2)CC1. InChi Code: InChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24). InChi Key: ZGRDYKFVDCFJCZ-UHFFFAOYSA-N.