AZD 3229

AZD 3229 is an inhibitor of c-Kit-driven cell proliferation. It selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1,378 nM). AZD 3229 (20 mg/kg twice per day) induces tumor regression in a Ba/F3 mouse xenograft model and a mouse allograft model using Ba/F3 cells expressing KIT-exon 11 del/V654A, a common mutation in gastrointestinal stromal tumors (GIST).Formal Name: N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-1H-1,2,3-triazole-1-acetamide. CAS Number: 2248003-60-1. Molecular Formula: C24H26FN7O3. Formula Weight: 479.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.3 mg/ml, PBS (pH 7.2): Partially soluble. lambdamax: 219, 235, 263, 312 nm. SMILES: COCCOC1=CC(F)=C(C(NC2=CC=C(NC(CN3N=NC(C(C)C)=C3)=O)C=C2)=NC=N4)C4=C1. InChi Code: InChI=1S/C24H26FN7O3/c1-15(2)21-12-32(31-30-21)13-22(33)28-16-4-6-17(7-5-16)29-24-23-19(25)10-18(35-9-8-34-3)11-20(23)26-14-27-24/h4-7,10-12,14-15H,8-9,13H2,1-3H3,(H,28,33)(H,26,27,29). InChi Key: FLJOFQUXYAWOPE-UHFFFAOYSA-N.