AZ 13705339

A PAK1 inhibitor (IC50 = 0.33 nM), selective for PAK1 over a panel of 117 kinases at 100 nM, binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively), inhibits S. enterica infection in HAP1 cells at 10 µM, inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils (IC50 = 59 nM). Formulation: A solid. InChI: InChI=1S/C33H36FN7O3S/c1-4-45(43,44)31-18-27(11-12-29(31)40-15-13-39(3)14-16-40)37-33-36-20-28(34)32(38-33)41(21-26-8-6-5-7-25(26)19-35)30-17-24(22-42)10-9-23(30)2/h5-12,17-18,20,42H,4,13-16,21-22H2,1-3H3,(H,36,37,38). InChIKey: WPFLVPJXKWCRQK-UHFFFAOYSA-N. SMILES: FC1=CN=C(NC2=CC=C(N3CCN(CC3)C)C(S(=O)(CC)=O)=C2)N=C1N(CC4=CC=CC=C4C#N)C5=C(C)C=CC(CO)=C5