Zu "K04409" wurden 112 Artikel gefunden!
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Anti-PAK1
Artikelnummer: A301-259A
Protein function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly...
| Schlagworte: | Anti-PAK1, Anti-PAK-1, Anti-p65-PAK, Anti-Alpha-PAK, EC=2.7.11.1, Anti-p21-activated kinase 1,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 165,00 €
Anti-PAK1 Polyclonal Antibody
Artikelnummer: E-AN100004P.100
P21-activated kinase-1 (PAK1) is an enzyme associated with multiple metabolic networks and different types of cancers.PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16 gene. The p21 protein...
| Schlagworte: | PAK-1, p68-PAK, Alpha-PAK, Protein kinase MUK2, p21-activated kinase 1, Serine/threonine-protein kinase PAK 1, PAK1... |
| Anwendung: | WB, ICC/IF, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | rat |
389,00 €
Anti-PAK1 Polyclonal Antibody
Artikelnummer: E-AN100003P.100
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc39 and Rac. This specific family member...
| Schlagworte: | PAK-1, p65-PAK, Alpha-PAK, p21-activated kinase 1, Serine/threonine-protein kinase PAK 1, PAK1 Antibody Polyclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
389,00 €
NVS-PAK1-1
Artikelnummer: Cay19964-5
NVS-PAK1-1 is an allosteric inhibitor of p21-activated kinase 1 (PAK1), a non-receptor serine/threonine kinase involved in tumorigenesis (Kd = 7 nM). It has an IC50 value of 5.2 nM in a PAK1 dephosphorylation assay. NVS-PAK1-1 is selective for PAK1 over PAK2 (Kd = 400 nM) and over a panel of 442 kinases, where it...
| Schlagworte: | (3S)-3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-1-pyrrolidine... |
| Anwendung: | Allosteric PAK1 inhibitor |
| CAS | 1783816-74-9 |
| MW: | 479.9 D |
ab 181,00 €
IPA-3
Artikelnummer: Cay14759-5
IPA-3 is an allosteric inhibitor of p21-activated kinase 1 (PAK1) activation (IC50 = 2.5 µM) that does not inhibit pre-activated PAK1. It selectively inhibits activation of the group I PAKs, PAK1, PAK2, and PAK3 over the group II PAKs, PAK4, PAK5, and PAK6 at 10 µM. IPA-3 inhibits the severe acute respiratory...
| Schlagworte: | 1,1'-dithiobis-2-naphthalenol |
| Anwendung: | PAK1 inhibitor |
| CAS | 42521-82-4 |
| MW: | 350.5 D |
ab 85,00 €
FRAX1036
Artikelnummer: Cay20711-1
FRAX1036 is a selective inhibitor of p21-activated kinase 1 (PAK1), a serine/threonine kinase downstream of Rac1 and Cdc42 that is involved in tumorigenesis. It can induce apoptosis in breast cancer cells and has been shown to potentiate the activity of the microtubule stabilizing agent, docetaxel (Cay-11637)....
| Schlagworte: | 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-pyrido[2,3-d]pyrimidin-7(8H... |
| Anwendung: | Potent, selective PAK1 inhibitor |
| CAS | 1432908-05-8 |
| MW: | 518.1 D |
ab 71,00 €
G-5555
Artikelnummer: Cay21469-5
G-5555 is an inhibitor of p21-activated kinase 1 (PAK1, Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50...
| Schlagworte: | 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimid... |
| Anwendung: | PAK1 Inhibitor |
| CAS | 1648863-90-4 |
| MW: | 493 D |
ab 67,00 €
FRAX486
Artikelnummer: TGM-T6840-2mg
Description: FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively. Target: PAK. Smiles: C(C)N1C=2C(C=C(C1=O)C3=C(Cl)C=C(Cl)C=C3)=CN=C(NC4=CC(F)=C(C=C4)N5CCNCC5)N2. References: Hayashi-Takagi A, et al. Proc Natl Acad Sci U S A....
| Anwendung: | PAK1 / PAK2 / PAK3 inhibitor |
| CAS | 1232030-35-1 |
| MW: | 513.39 D |
ab 34,00 €
Anti-phospho-PAK1 (Thr212)
Artikelnummer: ARG51653.100
Protein function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly...
| Schlagworte: | Anti-phospho-PAK1, Anti-phospho-PAK-1, Anti-phospho-p65-PAK, Anti-phospho-Alpha-PAK, EC=2.7.11.1,... |
| Anwendung: | ICC, IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 471,00 €
Anti-PAK1, Internal
Artikelnummer: ARG64016.100
Protein function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly...
| Schlagworte: | Anti-PAK1, Anti-PAK-1, Anti-p65-PAK, Anti-Alpha-PAK, EC=2.7.11.1, Anti-p21-activated kinase 1,... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse, rat |
871,00 €
Anti-PAK1
Artikelnummer: A301-260A
Protein function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly...
| Schlagworte: | Anti-PAK1, Anti-PAK-1, Anti-p65-PAK, Anti-Alpha-PAK, EC=2.7.11.1, Anti-p21-activated kinase 1,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
PAK1
Artikelnummer: BPS-40072
Active human PAK1 (GenBank Accession No. NM_002576.4), amino acids 248- 545, MW=33.6 kDa, expressed in E. coli.
| Schlagworte: | PAK-1, p65-PAK, Alpha-PAK, p21-activated kinase 1, Serine/threonine-protein kinase PAK 1, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 33.6 kD |
1.133,00 €