AVE-0991

AVE-0991 is an agonist of the Mas receptor, also known as the angiotensin (1-7) receptor. It binds to the Mas receptor in bovine aortic endothelial cell membranes and COS cells (IC50s = 21 and 47.5 nM, respectively). It reduces urinary volume in water-loaded mice, an effect that can be blocked by the angiotensin (1-7) antagonist A-779 (Cay-23396) and is reduced in Mas knockout mice. Dietary administration of AVE-0991 (0.58 µmol/kg per day) inhibits perivascular inflammation and increases plaque stability in an ApoE-/- mouse model of atherosclerosis. It also inhibits the formation of abdominal aortic aneurysm induced by angiotensin II in ApoE-/- mice.Formal Name: N-[(ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide. CAS Number: 304462-19-9. Molecular Formula: C29H32N4O5S2. Formula Weight: 580.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 230, 275, 305 nm. SMILES: O=CC1=C(OC)N=C(N1CC2=CC=C(C3=C(S(NC(NCC)=O)(=O)=O)SC(CC(C)C)=C3)C=C2)C4=CC=CC=C4. InChi Code: InChI=1S/C29H32N4O5S2/c1-5-30-29(35)32-40(36,37)28-24(16-23(39-28)15-19(2)3)21-13-11-20(12-14-21)17-33-25(18-34)27(38-4)31-26(33)22-9-7-6-8-10-22/h6-14,16,18-19H,5,15,17H2,1-4H3,(H2,30,32,35). InChi Key: QTOZBSNPDCWHPV-UHFFFAOYSA-N.