ATB-346

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen (Cay-70290). It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 µM. ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 µmol/kg. ATB-346 (30 µmol/kg) improves motor function in a mouse model of spinal cord injury.Formal Name: 6-methoxy-alpha-methyl-2-naphthaleneacetic acid, 4-(aminothioxomethyl)phenyl ester. CAS Number: 1226895-20-0. Molecular Formula: C21H19NO3S. Formula Weight: 365.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO:. lambdamax: 231 nm. SMILES: COC1=CC=C2C(C=CC(C(C)C(OC3=CC=C(C(N)=S)C=C3)=O)=C2)=C1. InChi Code: InChI=1S/C21H19NO3S/c1-13(21(23)25-18-8-5-14(6-9-18)20(22)26)15-3-4-17-12-19(24-2)10-7-16(17)11-15/h3-13H,1-2H3,(H2,22,26). InChi Key: YCNMAPLPQYQJFC-UHFFFAOYSA-N.