Astragaloside IV

White to off-white powder. Soluble in DMSO (30mg/ml) or DMF (20mg/ml). Chemical. CAS: 84687-43-4. Formula: C41H68O14. MW: 784.98. Astragaloside IV (AS-IV) is a bioactive saponin and constituent of the traditional chinese medicine plant Astragali radix. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antioxidative, anti-asthma, antidiabetes, anticancer, immunoregulation, neuroprotective and cardioprotective properties via numerous signaling pathways. This includes inhibition of NF-kappaB, inducing hypoxia-inducible factor-1alpha accumulation via PI3K/Akt pathway, reducing Abeta production in Alzheimer's disease through inhibition of BACE1, working as a natural PPARgamma agonist, improving lipid metabolism in obese mice, enhancing chemosensitivity through B7-H3 inhibition, and suppressing glucose-induced NLRP3 inflammasome activation.