ARN726

ARN726 is an inhibitor of N-acylethanolamine acid amidase (NAAA, IC50s = 27 and 63 nM for the human and rat enzyme, respectively). It is selective for NAAA over fatty acid amide hydrolase (FAAH) and acid ceramidase (IC50s = >100 and 12.5 µM, respectively), as well as a panel of 28 lipid metabolism- and inflammation-related enzymes at 10 µM. ARN726 (1-30 mg/kg) decreases lung myeloperoxidase activity and pleural exudate TNF-alpha levels in a mouse model of carrageenan-induced lung inflammation. It inhibits NAAA and reverses complete Freund's adjuvant-induced decreases in palmitoyl ethanolamide (PEA, Cay-90350) and oleoyl ethanolamide (OEA, Cay-90265) levels in inflamed paw tissue in a rat model of arthritis.Formal Name: N-[(3S)-2-oxo-3-azetidinyl]-carbamic acid, 4-cyclohexylbutyl ester. CAS Number: 1628343-77-0. Molecular Formula: C14H24N2O3. Formula Weight: 268.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml. SMILES: O=C(N[C@H]1CNC1=O)OCCCCC2CCCCC2. InChi Code: InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1. InChi Key: FNLUJRBWJBUJTC-LBPRGKRZSA-N.