AR231453

AR231453 is an agonist of GPR119. It increases cAMP accumulation in HIT-T15 beta cells that endogenously express high levels of GPR119 (EC50 = 4.7 nM). AR231453 increases insulin release from HIT-T15 cells (EC50 = 3.5 nM) and increases glucose-induced insulin release in isolated rat and mouse islets. It reduces plasma glucose levels in wild-type, KK/Ay, and db/db diabetic mice when administered at a dose of 20 mg/kg.Formal Name: N-[2-fluoro-4-(methylsulfonyl)phenyl]-6-[4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-5-nitro-4-pyrimidinamine. CAS Number: 733750-99-7. Molecular Formula: C21H24FN7O5S. Formula Weight: 505.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 3 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 285, 358 nm. SMILES: FC1=CC(S(=O)(C)=O)=CC=C1NC2=C([N+]([O-])=O)C(N3CCC(CC3)C4=NC(C(C)C)=NO4)=NC=N2. InChi Code: InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25). InChi Key: DGBKNTVAKIFYNU-UHFFFAOYSA-N.