AR 231453

Description: AR 231453 is a selective and orally available GPR119 agonist,can stimulate beta-cell replication and improve islet graft function. Target: GPR. Smiles: N(=O)(=O)C=1C(=NC=NC1NC2=C(F)C=C(S(C)(=O)=O)C=C2)N3CCC(CC3)C4=NC(C(C)C)=NO4. References: Chu ZL, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May,149(5):2038-47.