Apixaban-13C-d3

Apixaban-13C-d3 is intended for use as an internal standard for the quantification of apixaban (Cay-15427) by GC- or LC-MS. Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM). In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis.Formal Name: 4,5,6,7-tetrahydro-1-[4-(methoxy-13C-d3)phenyl]-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide. CAS Number: 1261393-15-0. Molecular Formula: C24[13C]H22D3N5O4. Formula Weight: 463.5. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml. SMILES: O=C1CCCCN1C2=CC=C(N3CCC(C(C(N)=O)=NN4C5=CC=C(O[13C]([2H])([2H])[2H])C=C5)=C4C3=O)C=C2. InChi Code: InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)/i1+1D3. InChi Key: QNZCBYKSOIHPEH-KQORAOOSSA-N.