AP-18

AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 µM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.Formal Name: 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime. CAS Number: 55224-94-7. Molecular Formula: C11H12ClNO. Formula Weight: 209.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 216, 274 nm. SMILES: ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1. InChi Code: InChI=1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+. InChi Key: MHTJEUOFLVQMCL-NJHPPEEMSA-N.