ANR 94

ANR 94 is an adenosine A2A receptor antagonist (Ki = 0.046 µM). It is selective for the adenosine A2A receptor over adenosine A1, -A2B, and -A3 receptors (Kis = 2.4, >30, and 21 µM, respectively). ANR 94 (5 mg/kg) reduces the number of parkinsonian-like tremors induced by tacrine (Cay70240) in rats. It decreases neurodegeneration and neuroinflammation in the substantia nigra pars compacta in a mouse model of MPTP-induced Parkinson's disease when administered at a dose of 0.5 mg/kg. ANR 94 (5 mg/kg) increases alcohol intake but not water or food intake in alcohol-preferring rats. SMILES CCOC1=NC2=C(N)N=CN=C2N1CC InChi Code InChI=1S/C9H13N5O/c1-3-14-8-6(7(10)11-5-12-8)13-9(14)15-4-2/h5H,3-4H2,1-2H3,(H2,10,11,12) InChi Key QUGDTMONBLMLLD-UHFFFAOYSA-N