AMX12006

AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM). It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces tumor volume alone or in combination with the 5-fluorouracil prodrug capecitabine (Cay-10487) in CT26 murine colon cancer models when administered at a dose of 150 mg/kg.Formal Name: 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-benzoic acid. CAS Number: 2639775-01-0. Molecular Formula: C26H22F3N3O3. Formula Weight: 481.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 241 nm. SMILES: O=C(C1=C(NC2=CC(C(F)(F)F)=CC=C2)C(C=CC=C3)=C3N1C)N[C@@H](C)C4=CC=C(C(O)=O)C=C4. InChi Code: InChI=1S/C26H22F3N3O3/c1-15(16-10-12-17(13-11-16)25(34)35)30-24(33)23-22(20-8-3-4-9-21(20)32(23)2)31-19-7-5-6-18(14-19)26(27,28)29/h3-15,31H,1-2H3,(H,30,33)(H,34,35)/t15-/m0/s1. InChi Key: BBJLZNHEYIHTCB-HNNXBMFYSA-N.