Amodiaquine-d10

Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine (Cay-15954) by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Cay-20822). It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.Formal Name: 2-((bis(ethyl-d5)amino)methyl)-4-((7-chloroquinolin-4-yl)amino)phenol. CAS Number: 1189449-70-4. Synonyms: Camoquine-d10, Flavoquine-d10. Molecular Formula: C20H12ClD10N3O. Formula Weight: 365.9. Purity: >99% deuterated forms (d1-d10). Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, Methanol: soluble. SMILES: OC(C=C1)=C(CN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])C=C1NC2=CC=NC3=C2C=CC(Cl)=C3. InChi Code: InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)/i1D3,2D3,3D2,4D2. InChi Key: OVCDSSHSILBFBN-MWUKXHIBSA-N.