AMI-193

A 5-HT2A and dopamine D2 receptor antagonist, selective for the 5-HT2A receptor over 5-HT2B and 5-HT1C receptors (Kis = 22.39, 977.24, and 1,548.82 nM, respectively) but does bind to the 5-HT1A receptor (Ki = 50 nM), selectively binds to the dopamine D2 receptor over the dopamine D1 receptor (Kis = 3 and 2,530 nM, respectively), completely inhibits amphetamine-induced increases in locomotor activity and rearing behavior in rats for at least three hours at 0.05 mg/kg, reduces amphetamine-induced increases in locomotor activity and rearing behavior in mice when used at doses of 0.15 and 0.2 mg/kg but the effects only last for 30 minutes. Formulation: A solid. InChI: InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27). InChIKey: FJUKDAZEABGEIH-UHFFFAOYSA-N. SMILES: FC(C=C1)=CC=C1OCCCN2CCC(C3=O)(N(C4=CC=CC=C4)CN3)CC2