AMG 208

AMG 208 is a potent inhibitor of c-Met (IC50 = 5.2 nM for wild-type c-Met). It also inhibits VEGF receptor 2 (VEGFR2, IC50 = 112 nM).Formal Name: 7-methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]-quinoline. CAS Number: 1002304-34-8. Molecular Formula: C22H17N5O2. Formula Weight: 383.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 231 nm. SMILES: COC1=CC2=NC=CC(OCC3=NN=C(C=C4)N3N=C4C5=CC=CC=C5)=C2C=C1. InChi Code: InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3. InChi Key: HEAIZQNMNCHNFD-UHFFFAOYSA-N.