AMG 009

A DP2/CRTH2 and DP1 dual antagonist (IC50s = 3 and 12 nM, respectively), decreases airway resistance in a guinea pig model of aerosolized PGD2-induced airflow obstruction at 3, 10, and 30 mg/kg. Formulation: A solid. InChI: InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32). InChIKey: DKSKRBVXRDGYAS-UHFFFAOYSA-N. SMILES: O=C(CC1=CC=C(C(OC)=C1)OC(C(NS(C2=CC=C(Cl)C=C2Cl)(=O)=O)=C3)=CC=C3C(NCCCC)=O)O