Zu "K06715" wurden 33 Artikel gefunden!
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CHO-K1/DP2/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00436
Recombinant CHO-K1 cells stably overexpress human prostaglandin D2 receptor 2 (DP2) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.
| Schlagworte: | PTGDR2, Prostaglandin D2 receptor 2, G-protein coupled receptor 44, Chemoattractant receptor-homologous molecule expressed... |
11.424,00 €
AMG 009
Artikelnummer: Cay42392-10
A DP2/CRTH2 and DP1 dual antagonist (IC50s = 3 and 12 nM, respectively), decreases airway resistance in a guinea pig model of aerosolized PGD2-induced airflow obstruction at 3, 10, and 30 mg/kg. Formulation: A solid. InChI:...
| Schlagworte: | 4-[4-[(butylamino)carbonyl]-2-[[(2,4- dichlorophenyl)sulfonyl]amino]phenoxy]- 3-methoxy-benzeneacetic acid |
| Anwendung: | Prostaglandin D2 receptor 2 (CRTH2) / PTGDR (Prostaglandin DP1 receptor) dual antagonist |
| CAS | 1027847-67-1 |
| MW: | 581.5 D |
ab 112,00 €
OC000459
Artikelnummer: Cay12027-25
OC000459 is a potent, selective DP2 antagonist that displaces [3H]prostaglandin D2 ([3H]PGD2) from human recombinant DP2 receptors (Ki = 13 nM), rat recombinant DP2 receptors (Ki = 3 nM), and human native DP2 (Ki = 4 nM, Th2 cell membranes) without interfering with the ligand binding properties of other prostanoid...
| Schlagworte: | 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid |
| Anwendung: | DP2 antagonist |
| CAS | 851723-84-7 |
| MW: | 348.4 D |
ab 102,00 €
CAY10595
Artikelnummer: Cay10012553-1
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10595, as a racemic mixture, is...
| Schlagworte: | 5-chloro-1'-[5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'pyrrolidine]-1(2H)-acetic acid |
| Anwendung: | CRTH2receptor antagonist, DP2 receptor antagonist |
| CAS | 916047-16-0 |
| MW: | 451.2 D |
ab 99,00 €
S-5751
Artikelnummer: Cay10004030-5
S-5751 is an antagonist of the prostaglandin D2 (PGD2) receptor DP1 (Ki = 1.6 nM) that shows at least 20-fold selectivity over receptors for thromboxane and prostacyclin, as well as the PGE2 receptor EP2. Orally administered S-5751 blocks PGD2-induced plasma exudation in the conjunctiva (ED50 = 0.099 mg/kg) and...
| Schlagworte: | (5Z)-7-[(1R,2R,3S,5S)-2-[[(5-hydroxybenzo[b]thien-3-yl)carbonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-3-yl]-5-heptenoic acid |
| Anwendung: | Prostaglandin D2 receptor (PTGDR) antagonist |
| CAS | 209268-36-0 |
| MW: | 441.6 D |
ab 73,00 €
Setipiprant
Artikelnummer: Cay28291-5
Setipiprant is an orally bioavailable antagonist of the prostaglandin D2 (PGD2, Cay-12010) receptor CRTH2/DP2 (IC50 = 6 nM for the human receptor). It is selective for CRTH2/DP2 over DP1 in a radioligand binding assay (IC50 = 1,290 nM) and the prostaglandin E2 (PGE2, Cay-14010) receptor subtypes EP2 and EP4 in a...
| Schlagworte: | ACT-129968, 8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid |
| Anwendung: | CRTH2/CD294 antagonist |
| CAS | 866460-33-5 |
| MW: | 402.4 D |
ab 73,00 €
Anti-CRTH2
Artikelnummer: 600-401-AP0
Anti-CRTH2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with CRTH2 from other sources has not been determined. Protein function: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-...
| Schlagworte: | Anti-CD294, Anti-CRTH2, Anti-PTGDR2, Anti-Prostaglandin D2 receptor 2, Anti-G-protein coupled receptor 44,... |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
Anti-CRTH2
Artikelnummer: 600-401-AP1
Anti-CRTH2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with CRTH2 from other sources has not been determined. Protein function: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-...
| Schlagworte: | Anti-CD294, Anti-CRTH2, Anti-PTGDR2, Anti-Prostaglandin D2 receptor 2, Anti-G-protein coupled receptor 44,... |
| Anwendung: | ELISA, IHC, IFM, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
848,00 €
LAS191859
Artikelnummer: Cay20238-1
LAS191859 is a potent antagonist of CRTH2/DP2 with IC50 values of 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively. It is selective for CRTH2/DP2 over a panel of 65 enzymes, ion channels, and transporters with 50s = 2 and 8.2 nM in isolated eosinophils...
| Schlagworte: | 1-[2-[[(cyclopropylcarbonyl)ethylamino]methyl]-4-(trifluoromethyl)phenyl]-6-methyl-1H-pyrrolo[2,3-b]pyridine-3-acetic acid |
| Anwendung: | Prostaglandin D2 receptor 2 antagonist |
| CAS | 1420071-13-1 |
| MW: | 459.5 D |
ab 235,00 €
BI-671800
Artikelnummer: Cay27638-1
BI-671800 is an antagonist of the prostaglandin D2 (PGD2, Cay-12010) receptor CRTH2/DP2 (IC50 = 42 nM in a radioligand binding assay). It binds selectively to CRTH2/DP2 over DP1, thromboxane, and prostacyclin receptors (IC50s = 25.6, 62.6, and >100 µM, respectively). BI-671800 inhibits PGD2-induced shape change in...
| Schlagworte: | AP-761, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-5-pyrimidineacetic acid |
| Anwendung: | Prostaglandin D2 receptor CRTH2/GPR44/CD294 antagonist |
| CAS | 1093108-50-9 |
| MW: | 501.5 D |
ab 102,00 €
Anti-PTGDR2
Artikelnummer: E-AB-18034.120
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide...
| Schlagworte: | Anti-CD294, Anti-CRTH2, Anti-PTGDR2, Anti-Prostaglandin D2 receptor 2, Anti-G-protein coupled receptor 44,... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
MK-7246
Artikelnummer: Cay34208-1
MK-7246 is an antagonist of the prostaglandin D2 (PGD2, Cay-12010) receptor CRTH2/DP2 (Ki = 2.5 nM). It is selective for CRTH2/DP2 over DP1, the PGF2alpha receptor (FP), the PGI2 receptor (IP), and the thromboxane A2 (TP) receptor (Kis = 373, >25,100, >23,030, and 3,804 nM, respectively), as well as the PGE2...
| Schlagworte: | (7R)-7-[[(4-fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-acetic acid |
| Anwendung: | CRTH2/DP2 receptor antagonist |
| CAS | 1218918-62-7 |
| MW: | 416.5 D |
ab 95,00 €