Amantadine (hydrochloride)

Amantadine is an NMDA receptor antagonist with IC50 values of 0.93, 0.82, and 0.47 µM at -70 mV for NR1-1a/NR2A, NR1-1a/NR2B, and NR1-1a/NR2D subunit-containing recombinant receptors, respectively, expressed in HEK293 cells. It blocks the influenza A M2 proton channel (IC50 = 16 µM for the recombinant channel expressed in Xenopus oocytes) and inhibits cytotoxicity induced by the influenza A strains H1N1 and H3N2 in MDCK cells (EC50s = 34 and 0.84 µM, respectively). It also improves the survival of mice infected with influenza A when administered 24 hours following viral challenge at a dose of 100 mg/kg per day. Amantadine (40 mg/kg) decreases dyskinesia induced by L-DOPA (Cay-13248) in a 6-OHDA hemi-parkinsonian mouse model. Formulations containing amantadine have been used in the treatment of various strains of influenza A virus infection and in the treatment of parkinsonism and drug-induced extrapyramidal symptoms.Formal Name: tricyclo[3.3.1.13,7]decan-1-amine, monohydrochloride. CAS Number: 665-66-7. Synonyms: Adamantylamine, Aminoadamantane, NSC 83653. Molecular Formula: C10H17N . HCl. Formula Weight: 187.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 50 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: NC1(C[C@H](C2)C3)C[C@@H]2C[C@@H]3C1.Cl. InChi Code: InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10,/h7-9H,1-6,11H2,1H/t7-,8+,9-,10?,. InChi Key: WOLHOYHSEKDWQH-GFZFNSNDSA-N.