Almorexant-13C-d3

Almorexant-13C-d3 is intended for use as an internal standard for the quantification of almorexant (Cay-13638) by GC- or LC-MS. Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay). It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg. Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.Formal Name: (R)-2-((S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-(methyl-13C-d3)-2-phenylacetamide. CAS Number: 2738376-75-3. Synonyms: ACT 078573-13C-d3. Molecular Formula: C28[13C]H28D3F3N2O3. Formula Weight: 516.6. Purity: >98% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Methanol: soluble. SMILES: O=C(N[13C]([2H])([2H])[2H])[C@@H](C1=CC=CC=C1)N2CCC3=C(C=C(OC)C(OC)=C3)[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4. InChi Code: InChI=1S/C29H31F3N2O3/c1-33-28(35)27(20-7-5-4-6-8-20)34-16-15-21-17-25(36-2)26(37-3)18-23(21)24(34)14-11-19-9-12-22(13-10-19)29(30,31)32/h4-10,12-13,17-18,24,27H,11,14-16H2,1-3H3,(H,33,35)/t24-,27+/m0/s1/i1+1D3. InChi Key: DKMACHNQISHMDN-AXIKUPSYSA-N.