ALK5 Inhibitor II

ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 µM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-beta signaling pathway and induction of Nanog transcription.Formal Name: 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine. CAS Number: 446859-33-2. Synonyms: E 616452, RepSox, SJN 2511. Molecular Formula: C17H13N5. Formula Weight: 287.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 331 nm. SMILES: CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1. InChi Code: InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22). InChi Key: LBPKYPYHDKKRFS-UHFFFAOYSA-N.