Aliskiren (hemifumarate)

Aliskiren is a nonpeptide inhibitor of renin (IC50 = 0.6 nM for the human enzyme). Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes. It also reduces cardiac hypertrophy and fibrosis induced by heart pressure overload in mice. Formulations containing aliskiren have been used in the treatment of hypertension.Formal Name: (alphaS,gammaS,deltaS,zetaS)-delta-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-gamma-hydroxy-4-methoxy-3-(3-methoxypropoxy)-alpha,zeta-bis(1-methylethyl)-benzeneoctanamide, 2E-butenedioate. CAS Number: 173334-58-2. Synonyms: CGP 60536, SPP 100. Molecular Formula: C30H53N3O6 . 1/2C4H4O4. Formula Weight: 609.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mg/mL, Ethanol: 100 mg/mL, Water: 100 mg/mL. lambdamax: 280 nm. SMILES: COC1=C(OCCCOC)C=C(C[C@H](C(C)C)C[C@H](N)[C@@H](O)C[C@H](C(NCC(C)(C)C(N)=O)=O)C(C)C)C=C1.OC(/C=C/C(O)=O)=O. InChi Code: InChI=1S/2C30H53N3O6.C4H4O4/c2*1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36,5-3(6)1-2-4(7)8/h2*10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35),1-2H,(H,5,6)(H,7,8). InChi Key: KLRSDBSKUSSCGU-KRQUFFFQSA-N.