Akt Inhibitor IV

Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a, IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM). It also reduces the growth of cancer cells (IC50 = 0.3 µM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).Formal Name: 6-(2-benzothiazolyl)-1-ethyl-2-[2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium, monoiodide. CAS Number: 681281-88-9. Molecular Formula: C31H27N4S . I. Formula Weight: 614.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 386 nm. SMILES: CC[N+]1=C(/C=C/N(C2=CC=CC=C2)C)N(C3=CC=CC=C3)C4=CC=C(C5=NC(C=CC=C6)=C6S5)C=C41.[I-]. InChi Code: InChI=1S/C31H27N4S.HI/c1-3-34-28-22-23(31-32-26-16-10-11-17-29(26)36-31)18-19-27(28)35(25-14-8-5-9-15-25)30(34)20-21-33(2)24-12-6-4-7-13-24,/h4-22H,3H2,1-2H3,1H/q+1,/p-1. InChi Key: NAYRELMNTQSBIN-UHFFFAOYSA-M.