AG-528

AG-528 is a tyrphostin that inhibits EGFR and HER2 (IC50s = 12 and 4.9 µM, respectively, for inhibition of autophosphorylation). It also inhibits pantothenate kinase 3 (PanK3, IC50 = 3 µM). AG-528 inhibits EGF-dependent proliferation of HER14 cells (IC50 = 25 µM).Formal Name: alphaE-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-beta-oxo-1H-indole-1-propanenitrile. CAS Number: 133550-49-9. Synonyms: Tyrphostin AG-528. Molecular Formula: C18H14N2O3. Formula Weight: 306.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 248, 363 nm. SMILES: O=C(/C(C#N)=C/C1=CC(O)=C(O)C=C1)N2CCC3=CC=CC=C32. InChi Code: InChI=1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+. InChi Key: MYKCTDWWIWGLHW-NTEUORMPSA-N.